RNF111抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: TM4 cell lysate, Primary antibody: P02824(RNF111 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P02824(RNF111 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The RNF111 antibody is a crucial tool for studying the Ring Finger Protein 111 (RNF111), also known as Arkadia, a member of the E3 ubiquitin ligase family. RNF111 plays a pivotal role in regulating cellular signaling pathways, particularly the TGF-β (Transforming Growth Factor-beta) pathway, by promoting the ubiquitination and subsequent degradation of negative regulators like SnoN and Ski. This process enhances TGF-β signaling, which is essential for diverse biological processes, including embryonic development, cell differentiation, and immune responses. Dysregulation of RNF111 has been implicated in diseases such as cancer, fibrosis, and developmental disorders.

The RNF111 antibody enables researchers to detect and quantify RNF111 expression in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. It aids in elucidating RNF111's molecular mechanisms, subcellular localization, and interactions with other proteins. Due to its role in modulating critical pathways, RNF111 is studied for potential therapeutic targets. Antibodies specific to RNF111 are validated for specificity and sensitivity, often targeting conserved domains like the RING finger or C-terminal regions.

Research using RNF111 antibodies has advanced understanding of its dual roles in promoting oncogenic TGF-β signaling and maintaining genomic stability, highlighting its context-dependent functions. These tools remain vital for exploring RNF111's contributions to disease progression and normal cellular homeostasis.