RPL28抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 231, HepG2 cell, Mouse liver tissue lysates, Primary antibody: P02823(RPL28 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 5 seconds    

  
  

The RPL28 antibody targets ribosomal protein L28 (RPL28), a component of the 60S subunit of eukaryotic ribosomes. Ribosomal proteins like RPL28 are essential for protein synthesis, playing structural and functional roles in ribosome assembly and mRNA translation. RPL28. encoded by the RPL28 gene in humans, contains conserved domains that facilitate interactions with rRNA and other ribosomal proteins. Beyond its canonical role, emerging studies suggest ribosomal proteins, including RPL28. may participate in extraribosomal processes such as DNA repair, apoptosis regulation, and cellular stress responses.

RPL28 antibodies are widely used in research to study ribosome biogenesis, translational control, and dysregulation in diseases. These antibodies enable detection and localization of RPL28 via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Specific applications include investigating RPL28 expression variations in cancers, developmental disorders, or conditions linked to ribosomopathies—diseases caused by impaired ribosome function. For example, altered RPL28 levels have been observed in certain tumors, potentially influencing cell proliferation.

Commercially available RPL28 antibodies are typically raised in hosts like rabbits or mice, with validation in model organisms (e.g., human, mouse, rat). Researchers must verify antibody specificity using knockout controls or siRNA knockdowns to minimize cross-reactivity, given the high homology among ribosomal protein family members. Overall, RPL28 antibodies serve as critical tools for dissecting both ribosomal and non-ribosomal functions of this protein in health and disease.