MRPS36抗体—艾普蒂

+ +

•  

   

     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue lysate, Primary antibody: P02808(MRPS36 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P02808(MRPS36 Antibody) at dilution 1/105. (Original magnification: ×200)    

  
  

The mitochondrial ribosomal protein S36 (MRPS36) is a component of the small subunit of the mitochondrial ribosome (mitoribosome), which is responsible for synthesizing proteins essential for oxidative phosphorylation (OXPHOS) and mitochondrial energy production. Unlike most mitoribosomal proteins, MRPS36 has no direct bacterial homolog, suggesting a specialized regulatory or structural role in mitochondrial translation. It is encoded by a nuclear gene, translated in the cytoplasm, and imported into mitochondria, where it integrates into the 28S small subunit of the mitoribosome.

MRPS36 antibodies are valuable tools for studying mitochondrial translation machinery and its dysfunction in diseases. These antibodies enable detection of MRPS36 expression levels, localization, and interactions via techniques like western blotting, immunofluorescence, and immunoprecipitation. Research applications include investigating mitochondrial disorders linked to impaired OXPHOS, cancer metabolism (where altered mitochondrial protein synthesis may support tumor growth), and neurodegenerative conditions like Parkinson’s disease. Some studies suggest MRPS36 may have extraribosomal roles in apoptosis or stress signaling, though its precise molecular functions remain under exploration.

Commercial MRPS36 antibodies are typically raised in rabbits or mice, with validation strategies involving gene knockdown/knockout controls to confirm specificity. Variability in post-translational modifications or tissue-specific isoforms may influence antibody performance. Recent interest in mitochondrial ribosome biology has driven the development of high-affinity MRPS36 antibodies for both basic research and diagnostic applications.