ZBED1抗体—艾普蒂

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     Western blot analysis of Hemopexin expression in human fetal liver lysate.    

  
  

ZBED1 (zinc finger BED domain-containing protein 1) is a nuclear protein encoded by the ZBED1 gene, implicated in transcriptional regulation and genome stability. It contains a characteristic BED (BEAF and DREF) zinc finger domain, enabling DNA binding and interactions with chromatin-modifying complexes. ZBED1 is evolutionarily conserved and ubiquitously expressed, with roles in cell proliferation, differentiation, and apoptosis. Studies suggest its involvement in maintaining heterochromatin structure, telomere dynamics, and retrotransposon silencing. Dysregulation of ZBED1 has been linked to cancer, neurodevelopmental disorders, and autoimmune diseases.

ZBED1 antibodies are essential tools for investigating its expression, localization, and molecular functions. These antibodies are commonly used in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Validated ZBED1 antibodies typically recognize specific epitopes within its N-terminal or BED domain, with cross-reactivity tested across human, mouse, and rat models. High-quality antibodies demonstrate specificity through knockout cell line controls or siRNA-mediated knockdown. Recent research employs ZBED1 antibodies to explore its interaction partners, post-translational modifications, and potential as a therapeutic target. Commercial antibodies often provide data on molecular weight (~75-80 kDa) and nuclear localization patterns. Proper validation remains critical due to homology with other BED domain proteins.