THADA抗体—艾普蒂

The THADA (Thyroid Adenoma Associated) gene, initially identified for its role in thyroid adenomas, encodes a protein implicated in various cellular processes, including apoptosis, glucose metabolism, and endoplasmic reticulum stress regulation. THADA antibodies are autoantibodies targeting this protein, often studied in the context of autoimmune and metabolic disorders. Research links THADA polymorphisms to type 2 diabetes, polycystic ovary syndrome (PCOS), and obesity, suggesting its broader metabolic influence. In autoimmune thyroid diseases (e.g., Graves' disease, Hashimoto's thyroiditis), THADA antibodies may reflect aberrant immune responses, though their exact pathogenic role remains unclear. Recent studies also explore THADA's involvement in cancers, particularly thyroid and prostate, where altered expression correlates with tumor progression. Detection of THADA antibodies aids in understanding disease mechanisms and identifying biomarkers for diagnosis or therapeutic targeting. However, clinical utility is still emerging, requiring further validation of their specificity and functional impact across conditions. Overall, THADA antibodies represent a nexus between autoimmunity, metabolism, and oncology, underscoring the gene's multifaceted biological significance.