WDR1抗体—艾普蒂

The WDR1 (WD repeat-containing protein 1) antibody is a research tool targeting the WDR1 protein, a conserved regulator of actin cytoskeleton dynamics. WDR1. also known as actin-interacting protein 1 (AIP1), facilitates cofilin-mediated actin filament disassembly by promoting severing and debranching. It contains WD40 repeats that mediate protein-protein interactions, enabling its role in cell motility, cytokinesis, and tissue morphogenesis. Dysregulation of WDR1 is linked to diseases, including autoinflammatory disorders (e.g., WDR1 deficiency syndrome) and cancers, where altered actin dynamics influence metastasis or therapy resistance. Antibodies against WDR1 are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study its expression, localization, and interactions in cellular pathways. They also aid in exploring WDR1's involvement in immune responses, apoptosis, and developmental processes. Commercially available WDR1 antibodies are typically raised in hosts like rabbits or mice, validated for specificity across human, mouse, and rat homologs. Recent studies highlight its therapeutic potential, driving demand for reliable antibodies to dissect molecular mechanisms in disease models or drug discovery.