NCLN抗体—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane 1-2: Human fetal liver tissue, A549 cells, Primary antibody: P00791(GC Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P00791(GC Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P00791(GC Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The NCLN antibody is a research tool designed to target Nicalin (NCLN), a conserved transmembrane protein primarily localized in the endoplasmic reticulum (ER). Nicalin plays a critical role in ER-associated processes, including protein complex assembly, signal transduction, and cellular homeostasis. It forms a complex with Nodal modulator (NOMO) and interacts with proteins like TMEM147. influencing pathways such as the Notch signaling cascade, which is vital for embryonic development and cell differentiation. Dysregulation of NCLN has been linked to developmental disorders and cancer progression.

NCLN antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study Nicalin's expression, subcellular localization, and interactions. Researchers employ these antibodies to explore its role in modulating the Notch pathway by regulating the cleavage of ligands such as DLL1. as well as its potential involvement in stress responses and apoptosis. Additionally, NCLN antibodies aid in investigating pathological mechanisms in congenital anomalies or malignancies, where Nicalin's function may be disrupted. Their specificity and reliability make them essential for elucidating NCLN's molecular mechanisms in both physiological and disease contexts.