SHMT2抗体—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 2 μg, Lane: Human plasma tissue, Primary antibody: P07826(AHSG Antibody) at dilution 1/1350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07826(AHSG Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P07826(AHSG Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

**Background of SHMT2 Antibody**

Serine hydroxymethyltransferase 2 (SHMT2) is a mitochondrial isoform of the SHMT enzyme family, which plays a critical role in one-carbon metabolism by catalyzing the reversible conversion of serine and tetrahydrofolate to glycine and 5.10-methylene tetrahydrofolate. This reaction is essential for nucleotide synthesis, methylation processes, and cellular redox balance. SHMT2 is highly expressed in rapidly proliferating cells, including cancer cells, where it supports biosynthetic demands and adapts to metabolic stress. Dysregulation of SHMT2 has been linked to tumor progression, chemoresistance, and poor clinical outcomes, making it a potential therapeutic target in oncology.

SHMT2 antibodies are immunological tools designed to detect and quantify SHMT2 protein levels in research applications. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study SHMT2 expression, subcellular localization, and interaction partners. These antibodies aid in exploring SHMT2's role in metabolic reprogramming, mitochondrial function, and disease mechanisms. Validated antibodies are critical for distinguishing SHMT2 from its cytosolic counterpart, SHMT1. and for investigating tissue-specific or cancer-associated expression patterns. Recent studies also highlight SHMT2's involvement in neurodegenerative diseases and developmental disorders, expanding its relevance beyond cancer research. Reliable SHMT2 antibodies thus serve as key reagents for advancing understanding of cellular metabolism and developing targeted therapies.