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网站主页 CDK18 antibody CDK18抗体
  • CDK18抗体—艾普蒂
  • CDK18抗体—艾普蒂
  • CDK18抗体—艾普蒂

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CDK18抗体—艾普蒂

Rabbit Polyclonal CDK18 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-16

上海切尔齐生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
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邮箱：ruihening88@163.com

产品详情:

中文名称：
CDK18抗体
英文名称：
Rabbit Polyclonal CDK18 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 2322 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
CDK18

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesFN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2
Entrez GeneID2335
clone2F4
WB Predicted band size262.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human FN1 expressed in E. Coli.  
FormulationAscitic fluid containing 0.03% sodium azide.

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Flow cytometric analysis of HeLa cells using FN1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using FN1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using FN1 mouse mAb with DAB staining.    


           

参考文献

以下是关于CDK18抗体的3-4篇文献示例及其摘要内容概括：

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1. **文献名称**: "CDK18 regulates cell cycle progression through CDC25C phosphorylation in response to DNA damage"

**作者**: Smith J, et al.

**摘要**: 本研究利用特异性CDK18抗体揭示了该激酶在DNA损伤应答中的作用。实验表明，CDK18通过磷酸化CDC25C调控G2/M检查点，影响细胞周期阻滞，提示其在基因组稳定性中的潜在功能。

2. **文献名称**: "Development and validation of a monoclonal antibody targeting CDK18 for cancer biomarker studies"

**作者**: Zhang L, et al.

**摘要**: 作者开发了一种高特异性抗CDK18单克隆抗体，并验证其在乳腺癌组织中的表达。结果显示CDK18在肿瘤样本中过表达，且与患者预后不良相关，支持其作为癌症生物标志物的潜力。

3. **文献名称**: "CDK18 modulates transcriptional elongation in a kinase-dependent manner"

**作者**: Johnson R, et al.

**摘要**: 通过免疫沉淀结合CDK18抗体，研究发现CDK18与RNA聚合酶II相互作用，调控基因转录延伸过程。其激酶活性影响多种致癌基因表达，提示CDK18在肿瘤发生中的转录调控作用。

4. **文献名称**: "Functional characterization of CDK18 antibodies in neurodegenerative models"

**作者**: Lee S, et al.

**摘要**: 该研究利用CDK18抗体探究其在神经退行性疾病中的表达变化。实验显示，CDK18在小鼠阿尔茨海默模型中表达上调，可能通过异常细胞周期重激活参与神经元死亡机制。

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注：上述文献信息为示例性概括，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。如需具体文献，建议补充时间范围或研究领域进一步筛选。

       

背景信息

CDK18 (Cyclin-Dependent Kinase 18) is a serine/threonine kinase belonging to the CDK family, which regulates critical cellular processes such as cell cycle progression, transcription, and RNA processing. Unlike canonical CDKs (e.g., CDK1. CDK2) directly driving cell cycle phases, CDK18 is classified as a transcriptional CDK, interacting with cyclin L to modulate RNA polymerase II activity and mRNA synthesis. It plays roles in transcription elongation, DNA damage response, and cell differentiation. Dysregulation of CDK18 has been implicated in cancers, including breast, liver, and colorectal cancers, where its overexpression or altered activity may influence tumor growth, metastasis, or therapeutic resistance.

CDK18 antibodies are essential tools for studying its expression, localization, and functional roles. They enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in biomarker research and mechanistic studies. Some antibodies target specific phosphorylated forms to assess activation status. While CDK18 is less characterized than other CDKs, emerging studies highlight its potential as a therapeutic target, driving demand for validated antibodies. Challenges include ensuring specificity due to high homology among CDK family members. Commercial CDK18 antibodies are typically developed using recombinant protein fragments or peptide immunogens, with validation in knockdown/knockout models to confirm reliability.

       
CDK18抗体;CDK18;CDK18 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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