RGP1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P02697(RGP1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

**Background of RGP1 Antibody**

The **RGP1 (Retinitis Pigmentosa GTPase Regulator-Interacting Protein 1)** antibody is a tool used to study the RGP1 protein, which plays roles in cellular processes such as ciliary function, intracellular trafficking, and cell signaling. RGP1. also known as **FAM91A1**, interacts with RPGR (Retinitis Pigmentosa GTPase Regulator), a protein critical for maintaining photoreceptor function in the retina. Mutations in RPGR are linked to X-linked retinitis pigmentosa (XLRP), a degenerative eye disease. RGP1's interaction with RPGR suggests involvement in ciliogenesis and retinal homeostasis, making it a focus in ocular disease research.

Structurally, RGP1 contains a conserved N-terminal coiled-coil domain, facilitating protein-protein interactions, and a C-terminal region implicated in membrane association. Beyond ophthalmology, RGP1 has been studied in cancer, where its dysregulation correlates with tumor progression and metastasis, potentially influencing cell migration pathways.

The RGP1 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression, localization, and interactions in tissues or cultured cells. It aids in elucidating RGP1's physiological roles and pathological mechanisms, particularly in retinal degeneration and cancer. Commercial RGP1 antibodies are typically developed in rabbits or mice, validated for specificity and sensitivity. Ongoing research aims to clarify RGP1's precise molecular functions and therapeutic potential, emphasizing its importance in both basic and clinical biomedical studies.