ARMC8抗体—艾普蒂

+ +

•  

   

     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse fat tissue, Primary antibody: P01654(PMP2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P01654(PMP2 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The ARMC8 (Armadillo Repeat Containing 8) protein is a component of the cullin-RING ubiquitin ligase (CRL) complex, which regulates ubiquitin-mediated protein degradation. It contains multiple Armadillo (ARM) repeats, structural motifs involved in protein-protein interactions. ARMC8 plays a critical role in substrate recognition and recruitment for the CRL complex, particularly in the β-TrCP1/2 (BTRC/FBXW11)-mediated ubiquitination pathway, impacting processes like Wnt/β-catenin signaling, cell cycle regulation, and DNA damage response. Dysregulation of ARMC8 has been linked to cancers, developmental disorders, and immune dysfunctions.

ARMC8 antibodies are essential tools for studying its expression, localization, and interactions. They are commonly used in techniques such as Western blotting, immunoprecipitation (IP), and immunofluorescence (IF) to investigate ARMC8's role in cellular pathways. Many commercially available antibodies target specific epitopes, often within the ARM repeat domains, and are validated for specificity using knockout cell lines or siRNA knockdown. Research applications include exploring ARMC8's involvement in tumor progression, ciliopathies, and viral infection mechanisms (e.g., HIV-1).

Recent studies highlight ARMC8's potential as a therapeutic target, driving demand for high-quality antibodies to support mechanistic and translational research. Validation data, including molecular weight confirmation (~50-55 kDa) and cross-reactivity profiles, are critical for ensuring experimental reliability.