ERGIC3抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: K562 cell lysate, Primary antibody: P02688(ERGIC3 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P02688(ERGIC3 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

ERGIC3 (ER-Golgi intermediate compartment 3) is a protein component of the ERGIC, a membrane-bound compartment involved in the transport of cargo between the endoplasmic reticulum (ER) and the Golgi apparatus. It is a conserved transmembrane protein that interacts with other ERGIC components, such as ERGIC1 and ERGIC2. to mediate vesicular trafficking and maintain secretory pathway integrity. ERGIC3 antibodies are immunological tools designed to detect and study this protein in various experimental settings, including Western blotting, immunofluorescence, and immunoprecipitation.

Research on ERGIC3 has linked it to critical cellular processes, including COPII vesicle formation, cargo sorting, and autophagy. Its role in viral replication, particularly for enveloped viruses like SARS-CoV-2. has drawn attention, as ERGIC membranes serve as platforms for viral assembly. Dysregulation of ERGIC3 has been implicated in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes, highlighting its broader physiological relevance. Antibodies against ERGIC3 enable researchers to investigate its expression levels, subcellular localization, and interactions under different conditions, providing insights into ER-Golgi dynamics and disease mechanisms. Commercial ERGIC3 antibodies are typically validated for specificity in model organisms like humans, mice, and rats, supporting cross-species studies.