PISD抗体—艾普蒂

The Phosphatidylserine Decarboxylase (PISD) antibody is a tool used to study the PISD enzyme, a key player in phospholipid metabolism. PISD catalyzes the decarboxylation of phosphatidylserine (PS) to phosphatidylethanolamine (PE), a critical step in maintaining membrane lipid homeostasis, particularly in mitochondria. This enzyme is embedded in the inner mitochondrial membrane and is essential for mitochondrial function, membrane integrity, and cellular processes like autophagy and apoptosis. Dysregulation of PISD has been linked to metabolic disorders, neurodegenerative diseases, and cancer, highlighting its biological significance. Researchers employ PISD antibodies to detect and quantify PISD protein levels, assess its subcellular localization, and investigate its role in disease mechanisms. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also explore PISD's potential as a therapeutic target, particularly in cancers reliant on mitochondrial lipid synthesis. The development of specific PISD antibodies has advanced understanding of lipid dynamics in health and disease, offering insights into mitochondrial dysfunction and opportunities for diagnostic or therapeutic innovations.