HMG20A抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P02670(HMG20A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P02670(HMG20A Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The HMG20A (High Mobility Group 20A) antibody is a tool used to study the HMG20A protein, a member of the non-histone chromosomal high mobility group (HMG) protein family. HMG20A, also termed HMGX or SOX21-like, contains an HMG-box domain that enables DNA binding and chromatin interaction. It plays roles in transcriptional regulation, chromatin remodeling, and epigenetic control, particularly in neural development and differentiation. Studies link HMG20A to neurogenesis, where it may act as a dual regulator—promoting neuronal differentiation while suppressing glial lineage commitment. It also interacts with chromatin-remodeling complexes like the Polycomb repressive complex (PRC2), influencing gene silencing.

HMG20A dysregulation is implicated in neurodevelopmental disorders (e.g., autism spectrum disorders) and cancers, including neuroblastoma and leukemia. The antibody is widely used in research to detect HMG20A expression levels, subcellular localization (primarily nuclear), and protein-protein interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its applications extend to exploring HMG20A's role in stem cell pluripotency, neuronal fate determination, and disease mechanisms. Recent work highlights its potential as a biomarker or therapeutic target in malignancies and neurological conditions. Commercial HMG20A antibodies are typically validated for specificity in human, mouse, or rat models.