CPVL抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human kidney tissue lysate, Primary antibody: P02571(CPVL Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P02571(CPVL Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of CPVL Antibody**

CPVL (Carboxypeptidase Vitellogenic Like) is a serine protease belonging to the carboxypeptidase family, initially identified through homology with vitellogenic carboxypeptidases in insects. It is expressed in various tissues, including immune cells like macrophages and dendritic cells, and is implicated in intracellular protein processing, particularly within the endoplasmic reticulum (ER) and lysosomal compartments. CPVL is suggested to play a role in antigen processing and presentation via MHC class I molecules, linking it to adaptive immune responses.

CPVL antibodies are tools used to detect and study the expression, localization, and function of CPVL in biological systems. Research highlights its potential involvement in diseases such as cancer, autoimmune disorders, and infections. For instance, altered CPVL expression has been observed in tumor-associated macrophages, suggesting a role in tumor microenvironment regulation. Additionally, genetic variants of CPVL are associated with susceptibility to tuberculosis, underscoring its relevance in infectious immunity.

These antibodies enable investigations into CPVL's enzymatic activity, interactions with substrates, and its regulatory mechanisms. They are critical for elucidating CPVL's contributions to cellular processes like protein degradation, immune modulation, and metabolic pathways. As interest grows in targeting proteases for therapeutic purposes, CPVL antibodies serve as vital reagents for both basic research and translational studies.