CETN3抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: TM4 cell lysate, Primary antibody: P02498(CETN3 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P02498(CETN3 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P02498(CETN3 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

**Background of CETN3 Antibody**

The CETN3 (centrin-3) antibody is a critical tool for studying the function and localization of CETN3. a member of the centrin family of calcium-binding proteins. Centrins are evolutionarily conserved, small EF-hand motif-containing proteins involved in microtubule-organizing centers (MTOCs), such as centrosomes and cilia. CETN3. specifically, plays roles in centrosome duplication, ciliogenesis, and DNA damage response. It interacts with other centrin family proteins (CETN1 and CETN2) and components of the centrosomal machinery, such as γ-tubulin and XPC (xeroderma pigmentosum group C) protein, linking it to cell cycle regulation and DNA repair pathways.

CETN3 antibodies are widely used in immunofluorescence, Western blotting, and immunoprecipitation to investigate CETN3 expression, subcellular localization, and protein-protein interactions. These antibodies help elucidate its involvement in diseases linked to centrosomal dysfunction, including ciliopathies, microcephaly, and cancers characterized by genomic instability. For instance, CETN3 dysregulation has been observed in certain carcinomas, suggesting its potential as a biomarker or therapeutic target.

Developed in various host species (e.g., rabbit, mouse), CETN3 antibodies are validated for specificity using knockout cell lines or siRNA-mediated knockdown. Their applications span basic research in cell biology, clinical studies, and drug discovery, making them indispensable for understanding centrin-mediated cellular processes and pathologies.