SLC3A2抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A375 and Jurkat cell lysates, Primary antibody: P02481(SLC3A2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P02481(SLC3A2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P02481(SLC3A2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The SLC3A2 antibody targets the solute carrier family 3 member 2 (SLC3A2), a transmembrane glycoprotein also known as CD98 or 4F2. SLC3A2 is a key component of heterodimeric amino acid transporters, forming complexes with light chains like SLC7A5 (LAT1) or SLC7A8 (LAT2) to mediate cellular uptake of neutral and cationic amino acids. These transporters play critical roles in nutrient sensing, cell growth, and immune regulation. SLC3A2 is ubiquitously expressed, particularly in proliferating cells, and is overexpressed in various cancers, where it supports tumor metabolism and metastasis.

SLC3A2 antibodies are widely used in research to study protein expression, localization, and function in normal and pathological contexts. They enable detection via techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry. Research highlights its involvement in mTOR signaling, T-cell activation, and tumor microenvironment adaptation. Dysregulation of SLC3A2 is linked to cancer progression, autoimmune disorders, and metabolic diseases, making it a potential therapeutic target.

Antibodies against SLC3A2 also aid in exploring its role in cell adhesion, as the protein interacts with integrins to regulate intracellular signaling pathways. Studies using these antibodies have advanced understanding of its dual roles in amino acid transport and integrin-mediated signaling, emphasizing its importance in cellular physiology and disease mechanisms.