CBFB抗体—艾普蒂

The CBFB (Core Binding Factor Beta) antibody is a crucial tool in studying the CBFB protein, a key component of the core-binding factor (CBF) complex. CBFB forms a heterodimer with RUNX family transcription factors (RUNX1. RUNX2. RUNX3), enhancing their DNA-binding affinity and stability. This complex regulates hematopoietic differentiation, skeletal development, and cellular proliferation. Dysregulation of CBFB, particularly through chromosomal translocations like inv(16)(p13q22) in acute myeloid leukemia (AML), leads to fusion proteins (e.g., CBFB-MYH11) that disrupt normal hematopoiesis. Antibodies targeting CBFB are widely used in research to detect its expression, localization, and interactions via techniques such as Western blot, immunohistochemistry, and co-immunoprecipitation. They also aid in studying CBFB's role in diseases, including leukemia, solid tumors, and developmental disorders. CBFB antibodies are essential for exploring molecular mechanisms in gene regulation, disease pathogenesis, and therapeutic targeting.