UTY抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P02366(UTY Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P02366(UTY Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The UTY antibody targets a protein encoded by the *UTY* (Ubiquitously Transcribed Tetratricopeptide Repeat-Containing, Y-Linked) gene, located on the Y chromosome. UTY is a male-specific histone demethylase belonging to the KDM6 family, which regulates gene expression by removing repressive histone H3 lysine 27 trimethylation (H3K27me3) marks. It shares functional homology with its X-linked paralog, UTX (KDM6A), but differs in substrate specificity and tissue expression patterns. UTY plays roles in immune regulation, cellular differentiation, and maintaining chromatin structure, with implications in sex-biased diseases.

Research on UTY antibodies has grown due to its involvement in sex-specific immune responses and cancer. For instance, UTY-derived peptides can act as minor histocompatibility antigens in male-to-female hematopoietic stem cell transplants, triggering graft-versus-host disease (GVHD). In oncology, UTY expression is linked to hematologic malignancies and prostate cancer, where it may influence epigenetic dysregulation. Antibodies against UTY are utilized to study protein localization, expression levels, and functional interactions in male-specific tissues or disease models.

Despite its Y-chromosome restriction, UTY’s role in immune evasion and epigenetic modulation highlights its broader relevance beyond gender-specific biology. Current studies focus on leveraging UTY-targeting tools for immunotherapy development and understanding sex disparities in disease progression.