UBE2T抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P02338(UBE2T Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

UBE2T (Ubiquitin-conjugating enzyme E2 T) is a member of the E2 ubiquitin-conjugating enzyme family, which plays a critical role in the ubiquitination cascade by transferring ubiquitin to target proteins in collaboration with E3 ligases. It is particularly notable for its involvement in the Fanconi anemia (FA) DNA repair pathway, where it interacts with FANCL, the E3 ligase component of the FA core complex. UBE2T-mediated ubiquitination of FANCD2 and FANCI is essential for activating the FA pathway, enabling repair of DNA interstrand crosslinks and maintaining genomic stability. Dysregulation of UBE2T has been linked to Fanconi anemia-related disorders and cancer, with studies showing its overexpression in various malignancies, including breast, liver, and lung cancers, where it may promote genomic instability and tumor progression.

Antibodies targeting UBE2T are vital tools for studying its expression, localization, and functional roles. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess UBE2T protein levels in cellular and tissue samples. Researchers also employ UBE2T-specific antibodies for co-immunoprecipitation assays to explore its interactions with pathway partners, such as FANCL or FANCD2. Additionally, these reagents help investigate UBE2T's post-translational modifications and its involvement in cellular stress responses. Given UBE2T's emerging role as a potential biomarker or therapeutic target in cancer, reliable antibodies are crucial for both basic research and clinical applications aimed at understanding disease mechanisms or developing targeted therapies.