WFS1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P02307(WFS1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P02307(WFS1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The WFS1 antibody targets the protein wolframin, encoded by the *WFS1* gene located on chromosome 4p16.1. Wolframin is a transmembrane glycoprotein primarily localized to the endoplasmic reticulum (ER), where it plays a role in regulating ER stress, calcium homeostasis, and cellular apoptosis. Mutations in *WFS1* are linked to Wolfram syndrome (WS), a rare autosomal recessive disorder characterized by diabetes mellitus, optic atrophy, deafness, and neurodegeneration. Beyond WS, *WFS1* variants are associated with psychiatric disorders, diabetes insipidus, and other neurological conditions, highlighting its broader role in cellular and metabolic pathways.

WFS1 antibodies are critical tools in research to investigate the protein’s expression, localization, and functional mechanisms. They are employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study tissue-specific expression patterns or disease-related alterations. Additionally, these antibodies aid in exploring wolframin’s interaction with ER chaperones and its involvement in stress-response pathways. Recent studies also utilize WFS1 antibodies to model Wolfram syndrome in cellular or animal systems, facilitating therapeutic development. Their application extends to potential diagnostic assays, though clinical use remains exploratory. Overall, WFS1 antibodies serve as essential reagents for unraveling the molecular basis of wolframin-related diseases and ER biology.