ZMAT2抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-6: Jurkat, 231, Hela, k562 and A172 cell, Mouse brain tissue lysates, Primary antibody: P02252(ZMAT2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P02252(ZMAT2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P02252(ZMAT2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The ZMAT2 (Zinc Finger Matrin-Type 2) antibody is a tool used to detect and study the ZMAT2 protein, encoded by the ZMAT2 gene in humans. ZMAT2 is a nuclear protein belonging to the zinc finger matrin family, characterized by conserved zinc finger motifs and a matrin-type domain. It plays a role in RNA metabolism, including pre-mRNA splicing, transcriptional regulation, and ribosome biogenesis. ZMAT2 is implicated in maintaining RNA stability and mediating interactions between RNA and proteins, which are critical for cellular processes like growth, differentiation, and stress responses.

Antibodies targeting ZMAT2 are typically developed in hosts such as rabbits or mice, often as monoclonal or polyclonal variants. They are widely used in techniques like Western blotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to investigate ZMAT2 expression, localization, and function in cell lines, tissues, or disease models. Research highlights ZMAT2's potential involvement in cancer progression, as dysregulation of RNA-processing proteins is common in tumors. Studies also explore its role in neurodegenerative diseases linked to RNA misprocessing.

Validated ZMAT2 antibodies are essential for distinguishing ZMAT2 from homologous family members (e.g., ZMAT1. ZMAT3) and require specificity testing via knockout controls. These reagents contribute to understanding ZMAT2's biological significance and its interplay in molecular pathways, aiding drug discovery and mechanistic studies.