TWSG1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse liver tissue, Rat liver tissue lysates, Primary antibody: P02200(TWSG1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P02200(TWSG1 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

TWSG1 (Twisted Gastrulation BMP Signaling Modulator 1) is a secreted glycoprotein belonging to the twisted gastrulation (TSG) family, initially identified for its role in embryonic development. It functions as an extracellular modulator of bone morphogenetic protein (BMP) signaling pathways, which are critical for skeletal formation, tissue homeostasis, and cellular differentiation. TWSG1 interacts with BMP ligands (e.g., BMP2. BMP4) and their antagonists (e.g., Chordin, Noggin), fine-tuning BMP activity in a context-dependent manner. This regulation influences osteoblast/osteoclast balance, hematopoiesis, and angiogenesis, linking TWSG1 to bone metabolism, cancer progression, and blood disorders.

TWSG1 antibodies are immunological tools designed to detect, quantify, or neutralize TWSG1 protein in research and clinical applications. Polyclonal or monoclonal antibodies target specific epitopes, enabling applications such as Western blotting, immunohistochemistry, flow cytometry, and ELISA. In research, these antibodies help elucidate TWSG1's dual roles in disease: it may act as a tumor suppressor by inhibiting BMP-driven oncogenesis or as a pro-tumor factor by promoting angiogenesis or immune evasion. Clinically, TWSG1 antibodies are explored for therapeutic potential in osteolytic disorders (e.g., osteoporosis) and cancers (e.g., multiple myeloma, breast cancer) where dysregulated BMP signaling contributes to pathogenesis. Challenges include understanding tissue-specific interactions and optimizing antibody specificity to minimize off-target effects.