DNAAF5抗体—艾普蒂 新品

The DNAAF5 antibody is a tool used to detect DNAAF5 (Dynein Axonemal Assembly Factor 5), a protein critical for the assembly of dynein arms in motile cilia. Also known as HEATR2. DNAAF5 belongs to a family of proteins involved in cytoplasmic preassembly of dynein complexes before their transport to cilia. Mutations in the DNAAF5 gene are linked to primary ciliary dyskinesia (PCD), a genetic disorder characterized by impaired mucociliary clearance, leading to chronic respiratory infections, infertility, and situs inversus. The antibody aids in studying DNAAF5's expression, localization, and interaction partners, helping elucidate its role in ciliogenesis and dynein arm formation. It is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein levels in cell lines or patient-derived samples. Commercially available DNAAF5 antibodies are typically raised in rabbits or mice, validated for specificity against recombinant or endogenous proteins. Research using this antibody has advanced understanding of ciliary dysfunction mechanisms and potential therapeutic targets for PCD. Its application also extends to developmental biology, given cilia's role in embryonic patterning. Proper validation, including knockout controls, is essential to ensure accurate detection due to potential cross-reactivity with structurally similar proteins.