COMMD10抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: HEPG2, 293T and Hela cell lysates, Primary antibody: P02179(COMMD10 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P02179(COMMD10 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P02179(COMMD10 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The COMMD10 antibody is a research tool used to detect COMMD10. a member of the copper metabolism MURR1 domain-containing (COMMD) protein family. COMMD10 plays roles in diverse cellular processes, including copper homeostasis, ion transport, NF-κB signaling regulation, and endosomal trafficking. It contains a conserved N-terminal COMM domain critical for protein-protein interactions and is ubiquitously expressed, with higher levels in tissues like the liver and kidneys. Dysregulation of COMMD10 has been linked to pathologies such as cancer, cardiovascular diseases, and neurodegenerative disorders.

COMMD10 antibodies are typically generated in hosts like rabbits or mice using immunogens derived from recombinant proteins or synthetic peptides corresponding to specific regions of the human COMMD10 sequence. These antibodies are validated for applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP). Specificity is confirmed using controls like knockout cell lines or siRNA-mediated knockdown.

As a key reagent, COMMD10 antibodies help elucidate the protein’s molecular interactions, subcellular localization, and involvement in disease mechanisms. Their utility extends to studying copper-related disorders (e.g., Wilson’s disease) and COMMD10’s emerging roles in cancer progression or immune regulation. Researchers prioritize antibodies with high batch-to-batch consistency and minimal cross-reactivity to ensure experimental reproducibility.