GMFB抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue  , Primary antibody: P02161(GMFB Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P02161(GMFB Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

GMFB (glia maturation factor beta) is a conserved 17 kDa protein first identified in the 1970s for its role in glial cell differentiation and neurodevelopment. It belongs to the GMF family, sharing structural homology with GMFG (gamma isoform). Primarily expressed in the central nervous system, GMFB localizes in astrocytes, microglia, and some neurons. Functionally, it acts as an intracellular signaling modulator, interacting with proteins like ARPC2 (actin-related protein 2/3 complex) to regulate cytoskeletal dynamics and inflammatory responses.

Research highlights GMFB's dual role in neuroprotection and neurodegeneration. It promotes neurite outgrowth under physiological conditions but becomes pathogenic when overexpressed during neuroinflammation. Elevated GMFB levels correlate with Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where it exacerbates glial activation, oxidative stress, and cytokine release (e.g., IL-1β, TNF-α). This pro-inflammatory activity links GMFB to blood-brain barrier disruption and neuronal apoptosis.

GMFB antibodies, developed as research tools, enable protein detection in immunoassays (Western blot, IHC/IF) and functional studies. Neutralizing antibodies are being explored to inhibit GMFB's pathological effects in preclinical models. Recent investigations also suggest extracellular GMFB secretion during cellular stress, expanding its potential as a therapeutic target and biomarker for neurological disorders. Current challenges include understanding isoform-specific functions and tissue-dependent signaling pathways.