RPS15抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P02134(RPS15 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The RPS15 antibody is a research tool designed to detect and study ribosomal protein S15 (RPS15), a component of the 40S subunit of eukaryotic ribosomes. RPS15 plays a critical role in ribosome biogenesis and protein synthesis by contributing to the assembly and stability of the ribosomal complex. Beyond its canonical role in translation, emerging studies suggest RPS15 may participate in extraribosomal functions, including cellular stress responses, apoptosis regulation, and interactions with viral or oncogenic proteins. Dysregulation of RPS15 has been linked to various diseases, including cancers (e.g., colorectal, liver) and ribosomopathies, where mutations in ribosomal proteins disrupt normal cellular function.

RPS15 antibodies, typically generated in rabbit or mouse hosts, are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to analyze protein expression, subcellular localization, and pathological correlations. Recent research highlights its potential as a biomarker for tumor progression or therapy resistance. Investigations into RPS15’s role in diseases often focus on its interaction with signaling pathways like p53 or MYC, offering insights into ribosome-mediated disease mechanisms. As ribosome biology gains attention in translational research, RPS15 antibodies remain vital for exploring therapeutic strategies targeting ribosomal dysfunction.