PIN4抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cell and Human fetal muscle tissue , Primary antibody: P02131(PIN4 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    

  
  

The PIN4 antibody targets the protein phosphatase 1 nuclear targeting subunit (PNUTS), also known as PPP1R10 or PIN4. which plays a critical role in regulating protein phosphatase 1 (PP1) activity. PP1 is a serine/threonine phosphatase involved in diverse cellular processes, including cell cycle progression, DNA damage response, and apoptosis. PIN4 acts as a scaffold protein, directing PP1 to specific substrates and modulating its enzymatic activity. Structurally, PIN4 contains multiple functional domains, such as TPR repeats and RNA-binding motifs, enabling interactions with PP1. RNA, and other partners.

PIN4 is implicated in maintaining genomic stability by facilitating DNA repair and checkpoint signaling. Studies highlight its role in dephosphorylating key proteins like tau, linking it to neurodegenerative diseases such as Alzheimer’s. Dysregulation of PIN4 has also been observed in cancers, where it may influence tumor progression through cell cycle control.

PIN4 antibodies are widely used in research to investigate PP1-mediated pathways, protein-RNA interactions, and disease mechanisms. They enable detection of PIN4 expression via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Recent work explores PIN4's therapeutic potential, particularly in targeting PP1 dysregulation in neurodegeneration and oncology. Its dual role in stress responses and cellular homeostasis makes PIN4 a compelling subject for both basic and translational studies.