METAP1D抗体—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 and 293T cell lysates, Primary antibody: P02114(METAP1D Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P02114(METAP1D Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P02114(METAP1D Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The METAP1D (Methionine Aminopeptidase 1D) antibody is a tool used to study the METAP1D enzyme, a member of the methionine aminopeptidase family. METAP1D plays a critical role in protein synthesis by catalyzing the removal of N-terminal methionine residues from nascent polypeptides, a post-translational modification essential for protein stability, function, and localization. This enzyme is particularly important in regulating processes like angiogenesis, cell proliferation, and apoptosis, with dysregulation linked to cancers, cardiovascular diseases, and neurological disorders.

METAP1D shares functional overlap with its isoform METAP2 but exhibits distinct tissue expression patterns and substrate specificities. The antibody targeting METAP1D enables researchers to detect and quantify its expression in various biological samples using techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It is crucial for investigating METAP1D's role in disease mechanisms, drug response studies, and validating its interaction with inhibitors or therapeutic compounds.

Most METAP1D antibodies are produced in rabbits or mice using immunogenic peptides or recombinant protein fragments. Specificity and cross-reactivity are key validation parameters, as METAP1D's homology with other METAP family members requires careful experimental design. Recent studies highlight METAP1D's potential as a biomarker in cancer prognosis and its involvement in metabolic pathways, driving interest in therapeutic targeting. Researchers rely on this antibody to explore METAP1D's contributions to cellular homeostasis and pathology, advancing both basic science and translational applications.