PDLIM1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A172 cells, Primary antibody: P01632(PDLIM1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P01632(PDLIM1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of PDLIM1 Antibody**

PDLIM1 (PDZ and LIM domain protein 1), also known as CLP-36 or CLIM1. is a cytoskeletal protein belonging to the PDZ-LIM family, characterized by its N-terminal PDZ domain and C-terminal LIM domain. It plays critical roles in cell adhesion, cytoskeletal organization, and signal transduction by interacting with actin-associated proteins, transcription factors, and signaling molecules. PDLIM1 is involved in regulating nuclear translocation of transcription factors like NF-κB and STAT, linking cytoskeletal dynamics to gene expression. Dysregulation of PDLIM1 has been implicated in cancer, inflammation, and cardiovascular diseases, with studies highlighting its dual roles as a tumor suppressor or promoter depending on context.

The PDLIM1 antibody is a vital tool for detecting and quantifying PDLIM1 expression in cells and tissues. It is widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to study its localization, protein-protein interactions, and functional mechanisms. Researchers employ this antibody to explore PDLIM1’s involvement in cellular processes, disease pathways, and therapeutic targeting. Validated for specificity and sensitivity, it aids in distinguishing PDLIM1 isoforms and post-translational modifications, providing insights into its context-dependent roles in health and disease. Commercial antibodies are typically raised in hosts like rabbits or mice, with clonal variants (monoclonal/polyoclonal) optimized for diverse experimental needs.