NDUFA2抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue lysate, Primary antibody: P01580(NDUFA2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P01580(NDUFA2 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P01580(NDUFA2 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The NDUFA2 antibody is a tool used to detect the NDUFA2 protein, a critical subunit of mitochondrial Complex I (NADH:ubiquinone oxidoreductase) in the electron transport chain. Complex I facilitates ATP production by transferring electrons from NADH to ubiquinone, coupled with proton translocation. NDUFA2. encoded by the nuclear *NDUFA2* gene, is essential for Complex I assembly and stability. Mutations in *NDUFA2* are linked to mitochondrial disorders, such as Leigh syndrome and Complex I deficiency, characterized by neurological degeneration, muscle weakness, and metabolic dysfunction.

NDUFA2 antibodies are widely used in research to study mitochondrial dysfunction, assess protein expression in disease models, and validate gene-editing outcomes. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to localize NDUFA2 within mitochondria or analyze its levels in tissues/cells. Commercially available antibodies are typically raised in rabbits or mice, targeting specific epitopes of human or murine NDUFA2. Validation includes testing in knockout controls or disease samples with known mutations. Reliable NDUFA2 antibodies are crucial for advancing insights into mitochondrial biology, disease mechanisms, and therapeutic strategies targeting energy metabolism pathways.