MCTS1抗体—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Jurkat cells, K562 cells, PC3 cells, A549 cells, Primary antibody: P01535(MCTS1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P01535(MCTS1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P01535(MCTS1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The MCTS1 (Malignant T-Cell-Amplified Sequence 1) gene, also known as MCTS1. encodes a protein implicated in regulating cell proliferation, translation, and oncogenesis. Initially identified through its amplification in aggressive T-cell lymphomas, MCTS1 is overexpressed in various cancers, including breast, colorectal, and hepatocellular carcinomas, correlating with poor prognosis. The protein interacts with translation initiation factors and mRNA-binding partners, potentially modulating the synthesis of oncogenic proteins like MYC. Its role in enhancing cap-dependent translation and promoting cell cycle progression highlights its significance in tumorigenesis.

MCTS1 antibodies are critical tools for studying its expression, localization, and function in cancer biology. They enable detection of MCTS1 in tissues or cell lines via techniques like Western blotting, immunohistochemistry, or immunofluorescence, aiding in biomarker validation. Researchers also use these antibodies to explore MCTS1's mechanistic contributions to therapy resistance or metastasis in preclinical models. Recent interest in targeting MCTS1 for anticancer therapies has spurred the development of inhibitory antibodies or small molecules. However, the protein's complex interactions and context-dependent roles necessitate further investigation. MCTS1 antibodies thus serve as both diagnostic probes and functional tools in unraveling its oncogenic potential.