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网站主页 MMP13 Antibody (C-term) MMP13抗体
  • MMP13抗体—艾普蒂
  • MMP13抗体—艾普蒂
  • MMP13抗体—艾普蒂

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MMP13抗体—艾普蒂

Rabbit Polyclonal MMP13 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-16

上海切尔齐生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
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邮箱：ruihening88@163.com

产品详情:

中文名称：
MMP13抗体
英文名称：
Rabbit Polyclonal MMP13 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1605 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
MMP13

验证与应用

应用及物种
WB1/500-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/10-1/50 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/500-1/5000 Human,Mouse,Rat
   

产品详情

AliasesCLG3, MANDP1
WB Predicted band size54 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human MMP13
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: P00082(MMP13 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P00082(MMP13 Antibody) at dilution 1/10. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human stomach cancer tissue using P00082(MMP13 Antibody) at dilution 1/10. (Original magnification: ×200)    


           

参考文献

以下是3-4条关于MMP13抗体的参考文献概览(信息基于公开研究整理，具体内容请参考原文)：

1. **文献名称**: "MMP13 promotes tumor invasion through collagen remodeling in the stromal microenvironment"

**作者**: Li et al.

**摘要**: 研究利用MMP13抗体检测肿瘤微环境中MMP13的分布，发现其通过降解胶原促进癌细胞侵袭，抗体阻断可抑制转移。

2. **文献名称**: "Regulation of MMP13 expression in osteoarthritis: Role of inflammatory cytokines"

**作者**: Wang et al.

**摘要**: 通过免疫组化(MMP13抗体标记)分析骨关节炎患者软骨组织，证实IL-1β和TNF-α上调MMP13表达，加速软骨退化。

3. **文献名称**: "Targeting MMP13 with a monoclonal antibody attenuates skeletal muscle fibrosis"

**作者**: Smith et al.

**摘要**: 开发一种高特异性MMP13单克隆抗体，在动物模型中验证其抑制纤维化相关胶原沉积的能力，提示治疗组织修复异常的潜力。

4. **文献名称**: "MMP13-neutralizing antibody therapy reduces angiogenesis in diabetic retinopathy models"

**作者**: Chen & Kumar

**摘要**: 利用MMP13抗体阻断酶活性，发现其可减少病理性血管生成，为糖尿病视网膜病变提供潜在治疗策略。

如需具体文章细节或全文链接，建议通过PubMed或期刊数据库检索作者及标题。

       

背景信息

Matrix metalloproteinase 13 (MMP13), a member of the MMP family, is a zinc-dependent endopeptidase involved in degrading extracellular matrix (ECM) components, particularly type II collagen. It plays critical roles in physiological processes like tissue remodeling, wound healing, and bone development, but its dysregulation is linked to pathological conditions such as osteoarthritis, cancer metastasis, and chronic inflammation. In osteoarthritis, MMP13 overexpression accelerates cartilage degradation by breaking down collagen networks, making it a key therapeutic target.

MMP13 antibodies are immunodetection tools designed to specifically recognize and bind to MMP13 proteins. These antibodies, often monoclonal or polyclonal, are widely used in research to study MMP13 expression patterns, localization, and activity in tissues or biofluids. Applications include immunohistochemistry, Western blotting, and ELISA. Some antibodies distinguish between latent (pro-MMP13) and active enzyme forms, aiding mechanistic studies. Additionally, therapeutic MMP13-neutralizing antibodies are under exploration to inhibit excessive collagenolysis in diseases like osteoarthritis, though challenges remain in balancing efficacy and off-target effects.

As a biomarker, MMP13 antibody-based assays help correlate enzyme levels with disease progression. Their development continues to advance understanding of MMP13's pathophysiological roles and potential intervention strategies.

       
MMP13抗体;MMP13;MMP13 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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