NRGN抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P00027(NRGN Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

**Background of Neurogranin (NRGN) Antibodies**

Neurogranin (NRGN) is a small, postsynaptic protein predominantly expressed in the brain, particularly in regions associated with learning and memory, such as the hippocampus and cerebral cortex. It plays a critical role in synaptic plasticity by binding calmodulin in a calcium-dependent manner, regulating intracellular calcium signaling and downstream pathways essential for cognitive functions.

NRGN has gained attention as a potential biomarker for neurodegenerative diseases, especially Alzheimer’s disease (AD). Studies show reduced NRGN levels in brain tissues of AD patients, while its cleavage products accumulate in cerebrospinal fluid (CSF), correlating with synaptic loss and disease progression.

Antibodies targeting NRGN are vital tools for both research and diagnostics. They enable the detection and quantification of NRGN in biological samples (e.g., CSF, plasma, or brain homogenates) using techniques like ELISA, Western blot, and immunohistochemistry. These antibodies help investigate NRGN’s role in synaptic integrity, its interaction with calmodulin, and its diagnostic utility in neurodegenerative conditions. Recent efforts focus on developing high-affinity, isoform-specific antibodies to improve assay sensitivity and explore therapeutic applications, such as modulating calcium signaling pathways. Challenges remain in standardizing assays and validating NRGN’s clinical relevance across diverse populations.