MRPL42抗体—艾普蒂

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     Flow cytometric analysis of HepG2 cells using MRPL42 mouse mAb (green) and negative control (purple).    

  
  

The MRPL42 antibody is a research tool designed to detect mitochondrial ribosomal protein L42 (MRPL42), a key component of the mitochondrial ribosome’s large subunit. MRPL42 is encoded by nuclear DNA and plays a critical role in mitochondrial protein synthesis by facilitating the assembly and stability of the ribosome. Mitochondrial ribosomes are responsible for translating mitochondrial DNA-encoded genes, particularly those involved in oxidative phosphorylation (OXPHOS), which generates cellular energy (ATP). Dysregulation of MRPL42 or mitochondrial ribosomal proteins has been linked to mitochondrial dysfunction, metabolic disorders, and diseases such as cancer or neurodegenerative conditions.

The MRPL42 antibody is commonly used in techniques like Western blotting, immunofluorescence, or immunohistochemistry to study protein expression, localization, and interactions in various tissues or cell lines. Researchers utilize it to explore mitochondrial biology, metabolic pathways, or disease mechanisms. Antibodies targeting MRPL42 are typically produced in hosts like rabbits or mice, with validation steps (e.g., knockout controls) to ensure specificity. Commercial suppliers often provide datasheets detailing applications, species reactivity, and experimental conditions. Recent studies have employed MRPL42 antibodies to investigate its role in cellular stress responses, cancer progression, or rare mitochondrial disorders, highlighting its relevance in both basic and translational research.