PDE1B抗体—艾普蒂

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Western blot analysis using PDE1B mouse mAb against PC-12 (1) cell lysate.    

  
  

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     Flow cytometric analysis of A549 cells using PDE1B mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using PDE1B mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using PDE1B mouse mAb with DAB staining.    

  
  

PDE1B (phosphodiesterase 1B) is a member of the calcium/calmodulin-dependent phosphodiesterase family, which hydrolyzes cyclic nucleotides cAMP and cGMP to regulate intracellular signaling. It is encoded by the *PDE1B* gene and primarily expressed in the brain, cardiovascular tissues, and immune cells. PDE1B plays a role in modulating neuronal plasticity, memory formation, vascular tone, and inflammatory responses. Its activity is tightly regulated by calcium signaling via binding to calmodulin, linking cyclic nucleotide metabolism to cellular Ca²⁺ dynamics.

Antibodies targeting PDE1B are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to quantify protein levels in tissues or cell lines. PDE1B-specific antibodies also aid in investigating its involvement in diseases such as neurodegenerative disorders (e.g., Alzheimer’s), cardiovascular diseases, and cancer, where dysregulated cyclic nucleotide signaling is implicated.

Research using PDE1B antibodies has highlighted its potential as a therapeutic target. Inhibitors of PDE1B are being explored for treating cognitive decline, hypertension, and immune disorders. However, antibody validation remains critical due to cross-reactivity risks with other PDE isoforms (e.g., PDE1A, PDE1C). Recent studies emphasize PDE1B's role in T-cell activation and neuroinflammation, expanding its relevance in immunology and neurology. Overall, PDE1B antibodies serve as pivotal reagents for unraveling its biological significance and translational applications.