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  • CD205抗体—艾普蒂
  • CD205抗体—艾普蒂
  • CD205抗体—艾普蒂

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CD205抗体—艾普蒂

Mouse Monoclonal CD205 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-16

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
CD205抗体
英文名称：
Mouse Monoclonal CD205 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1564 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
CD205

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesLY-75; CLEC13B; DEC-205; GP200-MR6
Entrez GeneID4065
clone4B10E11
WB Predicted band size198kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD205 (AA: free peptide) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of HL-60 cells using CD205 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of Jurkat cells using CD205 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of MOLT4 cells using CD205 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of THP-1 cells using CD205 mouse mAb (green) and negative control (red).    


           

参考文献

以下是关于CD205抗体的3篇参考文献及其摘要：

1. **"Targeting antigen to dendritic cell receptor DEC-205 enhances T cell activation and immunity"**

- **作者**: Bonifaz, L., et al.

- **摘要**: 该研究将模型抗原(如卵白蛋白)与抗DEC-205抗体偶联，靶向树突状细胞表面的DEC-205受体。实验表明，这种靶向策略显著增强了抗原提呈效率，并诱导了强烈的CD4+和CD8+ T细胞免疫应答，为疫苗开发提供了新思路。

2. **"Anti-CD205 antibody-drug conjugates for ovarian cancer therapy"**

- **作者**: Smith, J.D., et al.

- **摘要**: 研究开发了一种针对CD205的抗体药物偶联物(ADC)，通过将细胞毒素与抗CD205单克隆抗体结合，靶向高表达CD205的卵巢癌细胞。在动物模型中，该ADC显示出显著的肿瘤抑制效果，且对正常组织毒性较低。

3. **"Structural basis of DEC-205-mediated antigen processing in dendritic cells"**

- **作者**: Jiang, W., et al.

- **摘要**: 通过冷冻电镜技术解析了DEC-205受体的三维结构，揭示了其与抗原结合及内吞的关键结构域。研究阐明了DEC-205如何促进抗原进入溶酶体途径并参与MHC II类分子提呈的分子机制。

4. **"DEC-205 targeting promotes antigen-specific tolerance in autoimmune disease models"**

- **作者**: Hawiger, D., et al.

- **摘要**: 在稳态条件下，将自身抗原靶向DEC-205受体可诱导抗原特异性调节性T细胞(Treg)的生成，从而缓解实验性自身免疫性脑脊髓炎(EAE)。该策略为自身免疫性疾病的治疗提供了潜在途径。

这些文献涵盖了CD205抗体在疫苗开发、癌症靶向治疗、结构功能研究及免疫调节等领域的应用。

       

背景信息

CD205 antibody targets the CD205 antigen, also known as DEC-205 or LY75. a type C lectin receptor primarily expressed on antigen-presenting cells (APCs) such as dendritic cells (DCs) and macrophages. Discovered in the 1980s, CD205 is a member of the macrophage mannose receptor family and plays a critical role in antigen recognition, internalization, and processing. Its structure includes multiple ligand-binding domains, such as leucine-rich repeats and a fibronectin-type II domain, enabling interactions with pathogen-associated molecular patterns (PAMPs) and endogenous glycoproteins.

CD205 facilitates antigen uptake and directs internalized antigens to MHC class II compartments, promoting efficient antigen presentation to T cells. This property has made it a key target in immunology research, particularly in vaccine development and immunotherapy. Antibodies against CD205 are widely used to study DC biology, track APCs in tissues, or deliver antigens/therapeutics to these cells. For instance, anti-CD205 conjugates enhance vaccine efficacy by selectively delivering payloads to DCs, triggering robust adaptive immune responses.

In cancer immunotherapy, CD205 antibodies are explored for targeting tumor antigens or checkpoint inhibitors to DCs. However, their role in autoimmune diseases and tolerance induction is also under investigation. Commercially available CD205 antibodies (e.g., NLDC-145. MG38.1) vary in species reactivity and applications, necessitating careful selection based on experimental needs. Ongoing research continues to unravel its regulatory mechanisms and therapeutic potential.

       
CD205抗体;CD205;CD205 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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