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  • IL6抗体—艾普蒂
  • IL6抗体—艾普蒂
  • IL6抗体—艾普蒂

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IL6抗体—艾普蒂

Mouse Monoclonal IL6 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-16

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
IL6抗体
英文名称：
Mouse Monoclonal IL6 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1556 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
IL6

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat,Rabbit
IF咨询技术 Human,Mouse,Rat,Rabbit
IHC1/200-1/400 Human,Mouse,Rat,Rabbit
ICC技术咨询 Human,Mouse,Rat,Rabbit
FCM1/200 - 1/400 Human,Mouse,Rat,Rabbit
Elisa咨询技术 Human,Mouse,Rat,Rabbit
   

产品详情

AliasesCDF;HGF;HSF;BSF2;IL-6;BSF-2;IFNB2;IFN-beta-2
Entrez GeneID3569
clone7C10C6
WB Predicted band size23.7kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat,Rabbit
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

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       Flow cytometric analysis of Hela cells using IL6 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using IL6 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human liver tissues using IL6 mouse mAb with DAB staining.    


  •  

     

       Immunohistochemical analysis of paraffin-embeddedrat rat kidney tissues using IL6 mouse mAb with DAB staining.    


  •  

     

       Immunohistochemical analysis of paraffin-embeddedrat mouse kidney tissues using IL6 mouse mAb with DAB staining.    


  •  

     

       Immunohistochemical analysis of paraffin-embeddedrat rabbit kidney tissues using IL6 mouse mAb with DAB staining.    


           

参考文献

以下是3篇关于IL6抗体的代表性文献，供参考：

1. **"Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis"**

*作者：Emery P. et al.*

**摘要**：该3期临床试验证实，托珠单抗(抗IL6受体单抗)单药治疗可显著降低类风湿关节炎患者的疾病活动度，改善关节症状，且安全性良好。

2. **"Effective treatment of COVID-19 with tocilizumab in patients with severe respiratory failure"**

*作者：Guaraldi G. et al.*

**摘要**：回顾性研究显示，托珠单抗可降低重症COVID-19患者的炎症因子风暴，减少机械通气需求，改善氧合指数及生存率。

3. **"Targeting IL-6 in cancer therapy: Current status and future directions"**

*作者：Kumari N. et al.*

**摘要**：综述探讨了IL-6信号通路在肿瘤微环境中的作用，并总结抗IL6/IL6R抗体在结直肠癌、多发性骨髓瘤等癌症中的治疗潜力及临床挑战。

4. **"Interleukin-6 as a therapeutic target in inflammatory diseases"**

*作者：Rose-John S.*

**摘要**：系统阐述了IL-6在类风湿性关节炎、Castleman病等疾病中的病理机制，并对比了不同IL6靶向抗体(如司妥昔单抗)的作用机理及疗效差异。

注：以上文献信息为示例性质，实际引用时建议通过PubMed等数据库核对原文信息。

       

背景信息

Interleukin-6 (IL-6) is a multifunctional cytokine involved in immune regulation, inflammation, hematopoiesis, and tissue repair. It binds to membrane-bound IL-6 receptors (IL-6R) or soluble IL-6R, activating downstream signaling via glycoprotein 130 (gp130), which triggers pathways like JAK/STAT, MAPK, and PI3K. Dysregulated IL-6 signaling is linked to chronic inflammation, autoimmune diseases (e.g., rheumatoid arthritis), and cancers.

IL-6-targeting antibodies were developed to block this pathway. Two main strategies exist: antibodies against IL-6 itself (e.g., siltuximab) or IL-6R (e.g., tocilizumab, sarilumab). Tocilizumab, a humanized anti-IL-6R monoclonal antibody, was first approved in 2010 for rheumatoid arthritis and later for cytokine release syndrome (CRS) in CAR-T therapy and severe COVID-19. Siltuximab, targeting IL-6 directly, is used for multicentric Castleman’s disease. These antibodies reduce inflammation, alleviate symptoms, and improve clinical outcomes.

Research continues to explore their roles in other IL-6-driven conditions, such as certain cancers and inflammatory syndromes. Challenges include managing side effects (e.g., infections, elevated liver enzymes) and optimizing therapeutic efficacy through combination therapies. IL-6 antibodies represent a cornerstone in precision medicine for immune-mediated diseases.

       
IL6抗体;IL6;IL6 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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