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  • SMARCA2抗体—艾普蒂
  • SMARCA2抗体—艾普蒂
  • SMARCA2抗体—艾普蒂

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SMARCA2抗体—艾普蒂

Mouse Monoclonal SMARCA2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-16

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
SMARCA2抗体
英文名称：
Mouse Monoclonal SMARCA2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1555 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
SMARCA2

验证与应用

应用及物种
WB1/500-1/1000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200-1/400 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesBIS;BRM;SNF2;SWI2;hBRM;NCBRS;Sth1p;BAF190;SNF2L2;SNF2LA;hSNF2a
Entrez GeneID6595
clone7A5B2
WB Predicted band size181.3kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

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       Western blot analysis using SMARCA2 mouse mAb against Hela(1),HEK293(2),HepG2(3),A431(4) cell lysate.    


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       Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using SMARCA2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using SMARCA2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using SMARCA2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectal cancer tissues using SMARCA2 mouse mAb with DAB staining.    


           

参考文献

以下是3篇关于SMARCA2抗体的代表性文献(信息已简化整理)：

1. **文献名称**: "SMARCA2 deficiency confers resistance to NK cell-mediated cytotoxicity in non-small cell lung cancer"

**作者**: Li et al. (2022)

**摘要**: 该研究使用SMARCA2抗体(Western blot及免疫组化验证)发现，SMARCA2缺失通过调控HLA-I表达抑制NK细胞杀伤功能，揭示了其在肺癌免疫逃逸中的作用。

2. **文献名称**: "Dual targeting of BAF and MEK synergistically inhibits MYC-driven tumors"

**作者**: Alpsoy et al. (2021)

**摘要**: 通过SMARCA2抗体(ChIP-seq及免疫沉淀)证明SMARCA2与MYC启动子结合，其缺失导致染色质重塑异常，联合MEK抑制剂可协同抑制肿瘤生长。

3. **文献名称**: "SMARCA2 regulates a transcriptional program linking neuroblastoma differentiation to suppression of tumorigenicity"

**作者**: Wang et al. (2020)

**摘要**: 利用SMARCA2抗体(免疫荧光和流式细胞术)发现其在神经母细胞瘤分化中的关键作用，低表达与患者不良预后相关，机制涉及SOX10通路调控。

注：以上文献均为示例，实际引用需核对原文。建议通过PubMed搜索关键词“SMARCA2 antibody”或结合研究领域(如“SMARCA2 cancer”)筛选最新文献。若需实验抗体信息，可关注文献方法部分标注的抗体货号及供应商(如CST公司的#11976)。

       

背景信息

The SMARCA2 antibody is a critical tool for studying the SMARCA2 protein, a component of the SWI/SNF chromatin remodeling complex. This ATP-dependent complex regulates gene expression by altering chromatin structure, enabling access for transcriptional machinery. SMARCA2 (also known as BRM) shares homology with SMARCA4 (BRG1), another SWI/SNF subunit, and both possess helicase domains essential for chromatin remodeling. While SMARCA4 is more widely studied, SMARCA2 plays distinct roles in cellular differentiation, tumor suppression, and maintaining genomic stability. Dysregulation of SMARCA2 is implicated in cancers, particularly in contexts where SMARCA4 is lost, such as certain lung and liver cancers.

Antibodies targeting SMARCA2 are used to investigate its expression, localization, and interactions in normal and diseased tissues. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Specificity is crucial, as SMARCA2 shares structural domains with SMARCA4. and cross-reactivity must be ruled out. Researchers also employ these antibodies in chromatin immunoprecipitation (ChIP) to map SMARCA2-binding sites and study its role in gene regulation. In cancer research, SMARCA2 antibodies help assess its potential as a biomarker or therapeutic target, especially in SMARCA4-deficient malignancies. Validated antibodies are essential for distinguishing SMARCA2’s unique functions from those of its paralogs, advancing understanding of SWI/SNF complex dynamics in health and disease.

       
SMARCA2抗体;SMARCA2;SMARCA2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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