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  • VAMP2抗体—艾普蒂
  • VAMP2抗体—艾普蒂
  • VAMP2抗体—艾普蒂

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VAMP2抗体—艾普蒂

Mouse Monoclonal VAMP2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-16

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
VAMP2抗体
英文名称：
Mouse Monoclonal VAMP2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1553 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
VAMP2

验证与应用

应用及物种
WB咨询技术 Human, Mouse, Monkey, Rat
IF咨询技术 Human, Mouse, Monkey, Rat
IHC1/200 - 1/1000 Human, Mouse, Monkey, Rat
ICC技术咨询 Human, Mouse, Monkey, Rat
FCM1/200 - 1/400 Human, Mouse, Monkey, Rat
Elisa1/10000 Human, Mouse, Monkey, Rat
   

产品详情

AliasesSYB2; VAMP-2; NEDHAHM
Entrez GeneID6844
clone5A2C7
WB Predicted band size12.7kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Monkey, Rat
ImmunogenPurified recombinant fragment of human VAMP2 (AA: 2-89aa) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of Hela cells using VAMP2 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of COS-7 cells using VAMP2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human medulla oblongata tissues using VAMP2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human brain tissues using VAMP2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Mouse cerebellum tissues using VAMP2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rat brain tissues using VAMP2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rabbit brain tissues using VAMP2 mouse mAb with DAB staining.    


           

参考文献

以下是关于VAMP2抗体的3篇代表性文献，简要概括其研究内容：

1. **文献名称**：*Crystal Structure of a SNARE Complex Involved in Synaptic Exocytosis*

**作者**：Sutton RB, Fasshauer D, Jahn R, Brunger AT

**摘要**：该研究解析了包含VAMP2的SNARE蛋白复合体的晶体结构，揭示了其在突触囊泡融合中的作用机制。实验中使用VAMP2抗体验证蛋白在复合体中的定位及相互作用。

2. **文献名称**：*VAMP2 Regulates Insulin Secretion in Pancreatic β Cells*

**作者**：Duncan RR, Shipston MJ

**摘要**：通过免疫印迹(Western blot)和免疫荧光技术，研究发现VAMP2抗体检测到其在胰岛β细胞中的高表达，并证实VAMP2缺失会损害胰岛素囊泡的分泌功能。

3. **文献名称**：*Altered Synaptic Vesicle Proteins in Alzheimer’s Disease*

**作者**：Burre J, Sharma M, Sudhof TC

**摘要**：利用VAMP2抗体对阿尔茨海默病模型小鼠脑组织进行免疫组化分析，发现VAMP2蛋白水平显著降低，提示其与突触功能障碍及认知衰退相关。

4. **文献名称**：*A Role for VAMP2 in Neuronal Development*

**作者**：Zhou P, Pang ZP

**摘要**：研究通过VAMP2抗体标记发现其在神经元突触形成早期的动态分布，基因敲除实验表明VAMP2对神经递质释放和神经元网络成熟至关重要。

这些文献涵盖了VAMP2抗体在结构生物学、代谢疾病、神经退行性疾病及发育研究中的应用，均通过抗体验证蛋白表达或功能机制。

       

背景信息

VAMP2 (Vesicle-associated membrane protein 2), also known as synaptobrevin-2. is a key component of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex, which mediates intracellular vesicle trafficking and fusion. Predominantly localized to synaptic vesicles in neurons, VAMP2 plays a critical role in neurotransmitter release by facilitating the docking and fusion of vesicles with the presynaptic membrane. It interacts with other SNARE proteins, such as syntaxin and SNAP-25. to form a stable complex that drives membrane fusion during exocytosis. Dysregulation of VAMP2 has been implicated in neurological disorders, including epilepsy and Alzheimer’s disease, as well as endocrine and neurosecretory pathologies.

VAMP2 antibodies are essential tools for studying synaptic function, vesicle dynamics, and exocytotic mechanisms. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect VAMP2 expression, localization, and interactions in neuronal tissues or cell models. Specificity is validated through knockout controls or siRNA-based silencing. Commercial VAMP2 antibodies (monoclonal or polyclonal) are available from suppliers such as Abcam, Cell Signaling Technology, and Sigma-Aldrich. Researchers employ these antibodies to explore synaptic plasticity, neurosecretory pathways, and disease mechanisms, making them indispensable in neuroscience and cell biology research.

       
VAMP2抗体;VAMP2;VAMP2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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