MRP3抗体—艾普蒂 新品

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of HepG2 cells using MRP3 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using MRP3 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using MRP3 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using MRP3 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded breast cancer tissues using MRP3 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded mouse colon tissues using MRP3 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded mouse spleen tissues using MRP3 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded rat kidney tissues using MRP3 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded rat spleen tissues using MRP3 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded rabbit rectum tissues using MRP3 mouse mAb with DAB staining.    

  
  

The Multidrug Resistance-Associated Protein 3 (MRP3/ABCC3) is a member of the ATP-binding cassette (ABC) transporter superfamily, known for its role in cellular detoxification and drug resistance. Primarily expressed in the liver, intestine, kidneys, and adrenal glands, MRP3 transports a wide range of endogenous and exogenous organic anions, including conjugated metabolites (e.g., bilirubin glucuronides), bile acids, and certain chemotherapeutic agents. Unlike other MRP family members, MRP3 localizes to the basolateral membrane of polarized cells, facilitating substrate efflux into systemic circulation rather than luminal excretion. This unique trafficking pattern links MRP3 to physiological processes like bile acid homeostasis and pathological conditions such as cholestasis, hyperbilirubinemia, and chemotherapy resistance.

MRP3 antibodies are critical tools for studying its expression patterns, subcellular localization, and functional roles. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research applications span oncology (analyzing drug resistance mechanisms), hepatology (investigating cholestatic liver diseases), and pharmacology (assessing drug disposition). Commercially available MRP3 antibodies vary in specificity, often targeting distinct epitopes within its cytoplasmic or extracellular domains. Validation remains essential due to potential cross-reactivity with other ABC transporters. Recent studies also explore MRP3's involvement in metabolic diseases and inflammation, expanding its relevance beyond classical detoxification pathways.