ACHE抗体—艾普蒂

+ +

•  

   

     Western blot analysis using ACHE mouse mAb against PC-12 (1), Hela (2),mouse brai (3),NIH/3T3 (4),COS7 (5),Jurkat (6) and Raji (7) cell lysate.    

  
  

•  

   

     Flow cytometric analysis of NIH/3T3 cells using ACHE mouse mAb (green) and negative control (red).    

  
  

•  

   

     Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues using ACHE mouse mAb with DAB staining.    

  
  

•  

   

     Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using ACHE mouse mAb with DAB staining.    

  
  

Acetylcholinesterase (AChE) antibodies are immunological tools or autoantibodies targeting the enzyme acetylcholinesterase, which plays a critical role in terminating synaptic transmission at cholinergic synapses and neuromuscular junctions by hydrolyzing the neurotransmitter acetylcholine. AChE is widely expressed in the nervous system, muscles, and erythrocytes. Antibodies against AChE have garnered attention in both research and clinical contexts.

In research, AChE antibodies are used to study the enzyme's localization, expression, and function in tissues, aiding investigations into neurodegenerative diseases (e.g., Alzheimer’s) where cholinergic signaling is impaired. Clinically, autoantibodies to AChE are rare but have been implicated in certain autoimmune disorders. For example, they may interfere with neuromuscular signaling, potentially contributing to myasthenia-like symptoms. Additionally, AChE inhibitors (distinct from antibodies) are therapeutic agents for Alzheimer’s and myasthenia gravis, making AChE antibody studies relevant for understanding drug mechanisms or resistance.

Emerging studies also explore AChE's non-neuronal roles, such as in cell adhesion and apoptosis, where antibodies help elucidate these pathways. However, the pathophysiological significance of naturally occurring AChE autoantibodies remains less understood compared to other neural autoantibodies. Overall, AChE antibodies serve as vital probes in neuroscience and potential biomarkers or therapeutic targets in specific diseases.