USP11抗体—艾普蒂

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     Western blot analysis using USP11 mouse mAb against Hela (1), LNcap (2), HepG2 (3), K562 (4), A549 (5) and Jurkat (6) cell lysate.    

  
  

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     Flow cytometric analysis of Jurkat cells using USP11 mouse mAb (green) and negative control (red).    

  
  

USP11 (Ubiquitin-Specific Protease 11) is a deubiquitinating enzyme (DUB) belonging to the ubiquitin-specific protease family. It plays a critical role in regulating protein stability, DNA damage repair, and cellular signaling by removing ubiquitin chains from target proteins. USP11 is involved in key pathways such as the DNA damage response (e.g., interacting with BRCA1 and BRCA2), TGF-β signaling, and apoptosis. Dysregulation of USP11 has been linked to cancer progression, neurodegenerative diseases, and immune disorders, making it a potential therapeutic target.

USP11 antibodies are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunofluorescence, immunoprecipitation, and immunohistochemistry. Researchers rely on these antibodies to investigate USP11's role in cellular processes, including its interaction with substrates like p53. IκBα, and γ-tubulin. Specificity and validation are critical, as cross-reactivity with other DUBs (e.g., USP7 or USP15) may occur. Commercial USP11 antibodies are available in polyclonal or monoclonal forms, often developed in hosts like rabbit or mouse. Recent studies also explore USP11 inhibitors, highlighting the antibody's utility in preclinical research for targeting USP11-associated pathologies.