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NPM2抗体—艾普蒂新品

Mouse Monoclonal NPM2 Antibody

询价 20μl 起订

50μl 起订

100μl 起订

上海更新日期：2025-05-16

上海切尔齐生物科技有限公司

VIP1年

联系人：周经理

电话：027-19371278702拨打

手机：18008634902 拨打

邮箱：ruihening88@163.com

产品详情:

中文名称：: NPM2抗体

英文名称：: Mouse Monoclonal NPM2 Antibody

品牌：: 艾普蒂

产地：: 武汉

保存条件：: Stored at -20°C for 1511 year. Avoid repeated freeze / thaw cycles.

产品类别：: 抗体

重组：: 否

应用：: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA

种属反应性：: Human,Mouse,Rat

宿主：: Mouse

偶联物：: 无

靶点：: NPM2

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	1/200 - 1/1000	Human,Mouse,Rat
ICC	1/100 - 1/400	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	1/10000	Human,Mouse,Rat

产品详情

Entrez GeneID	10361
clone	1A6D4
WB Predicted band size	24.1kDa
Host/Isotype	Mouse IgG2b
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human NPM2 (AA: 1-214) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

+ +

Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Immunofluorescence analysis of Hela cells using NPM2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
Immunohistochemical analysis of paraffin-embedded human thyroid cancer tissues using NPM2 mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human brain tissues using NPM2 mouse mAb with DAB staining.

参考文献

以下是关于NPM2抗体的3篇参考文献及其摘要概括：

1. **"Nucleoplasmin 2 is required for proper chromatin organization in mouse oocytes"**

- **作者**: Inoue, N., et al. (2011)

- **摘要**: 研究利用NPM2抗体探究小鼠卵母细胞中NPM2蛋白在染色质重塑和表观遗传调控中的作用，发现其缺失导致胚胎发育异常。

2. **"The role of nucleoplasmin 2 (NPM2) in early embryonic development"**

- **作者**: Burns, K.H., et al. (2003)

- **摘要**: 通过免疫荧光和NPM2抗体定位，揭示NPM2在非洲爪蟾胚胎中作为染色质组装因子的功能，参与核仁前体结构的形成。

3. **"NPM2 interacts with the linker histone H1 and is essential for oocyte genome integrity"**

- **作者**: Okuda, M., et al. (2010)

- **摘要**: 研究使用NPM2抗体证明其在哺乳动物卵母细胞中通过与组蛋白H1互作维持基因组稳定性，并调控DNA损伤修复通路。

这些文献均通过NPM2抗体研究该蛋白的生物学功能，涵盖生殖细胞发育、染色质动态调控及基因组完整性等领域。建议结合具体研究方向进一步筛选。

背景信息

The NPM2 (Nucleophosmin 2) antibody is a tool used to study the NPM2 protein, a member of the nucleophosmin/nucleoplasmin family. NPM2 is primarily expressed in oocytes and early embryos, playing a critical role in chromatin remodeling, epigenetic regulation, and embryonic development. Unlike its well-characterized homolog NPM1. which is involved in ribosome biogenesis and cell cycle regulation, NPM2 is specifically associated with reproductive biology. It facilitates histone storage and exchange during gametogenesis, ensuring proper chromatin organization in gametes and zygotes. Studies suggest NPM2 deficiency disrupts early embryogenesis, leading to developmental arrest or abnormalities.

NPM2 antibodies are essential for detecting and quantifying the protein in experimental models, including immunofluorescence, Western blotting, and immunohistochemistry. They have been instrumental in exploring NPM2's interaction with histones, protamines, and other chromatin-associated factors. Research also links NPM2 dysregulation to reproductive disorders and certain cancers, though its oncogenic role remains less defined compared to NPM1. Recent interest in NPM2 antibodies has grown due to their potential applications in fertility research, regenerative medicine, and understanding epigenetic mechanisms in early development. However, the antibody's specificity requires careful validation due to structural similarities within the nucleophosmin family.

NPM2抗体;NPM2;NPM2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期	(2年)
注册资本	20万人民币
员工人数	1-10人
年营业额	￥ 100万以内
经营模式	贸易,工厂,试剂,定制,服务
主营行业	抗体,蛋白组学,细胞生物学