CD81抗体—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Western blot analysis using CD81 mouse mAb against Ramos (1), HEK293 (2),HepG2 (3), and C6 (4) cell lysate.    

  
  

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     Flow cytometric analysis of THP-1 cells using CD81 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human tonsil tissues using CD81 mouse mAb with DAB staining.    

  
  

CD81 antibody targets the CD81 protein, a widely expressed cell surface glycoprotein belonging to the tetraspanin superfamily. Characterized by four transmembrane domains, CD81 forms dynamic complexes with other membrane proteins (e.g., CD19. CD21) to regulate cellular processes like adhesion, signaling, and cell-cell interactions. It plays critical roles in immune modulation, notably as a co-receptor in B-cell activation and development. CD81 also gained prominence as a key entry receptor for hepatitis C virus (HCV), interacting with the viral E2 glycoprotein to facilitate infection.

CD81 antibodies are essential tools in research and diagnostics. They are used to study protein localization, membrane protein interactions, and immune cell functions via techniques like flow cytometry, immunoprecipitation, and immunofluorescence. In clinical contexts, CD81 antibodies help investigate CD81's involvement in diseases, including HCV infection, cancers (e.g., lymphoma, melanoma), and autoimmune disorders. Some therapeutic strategies explore blocking CD81-HCV interactions to prevent viral entry. However, CD81's pleiotropic roles require careful interpretation of antibody-based findings to avoid off-target effects.

Overall, CD81 antibodies bridge fundamental research and translational applications, offering insights into both physiological mechanisms and pathogenic pathways.