CD160抗体—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of Jurkat cells using CD160 mouse mAb (green) and negative control (red).    

  
  

CD160 is a cell surface glycoprotein belonging to the immunoglobulin superfamily, primarily expressed on natural killer (NK) cells, cytotoxic T lymphocytes, and subsets of γδ T cells. It functions as a activating or co-stimulatory receptor, depending on cellular context and ligand interactions. CD160 binds to herpesvirus entry mediator (HVEM), a TNF receptor family member, and this interaction plays a dual role in immune regulation: promoting NK cell-mediated cytotoxicity while also delivering inhibitory signals in chronic inflammatory settings.

CD160 antibodies have emerged as valuable tools for studying immune cell functions and therapeutic development. In research, they are used to block CD160-HVEM interactions, helping to elucidate pathways in viral immunity, tumor surveillance, and autoimmune disorders. Therapeutically, anti-CD160 antibodies are explored for enhancing anti-tumor immunity by preventing CD160-mediated exhaustion of T cells in the tumor microenvironment. Conversely, agonist antibodies might suppress excessive immune activation in autoimmune diseases.

Recent studies highlight CD160's role in endothelial cell biology, particularly in angiogenesis, expanding its relevance to cancer and vascular diseases. Challenges remain in understanding context-dependent signaling and optimizing antibody specificity. CD160 antibodies, both monoclonal and polyclonal, continue to support basic research and drug discovery, bridging gaps between immune modulation and disease pathology.