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  • CYCS抗体—艾普蒂
  • CYCS抗体—艾普蒂
  • CYCS抗体—艾普蒂

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CYCS抗体—艾普蒂

Mouse Monoclonal CYCS Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-15

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
CYCS抗体
英文名称：
Mouse Monoclonal CYCS Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1250 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
CYCS

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCYC; HCS; THC4
Entrez GeneID54205
clone5E6B11
WB Predicted band size11.7kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenPurified recombinant fragment of human CYCS (AA: 1-105) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using CYCS mouse mAb against Hela (1), Jurkat (2), RAW264.7 (3), NIH/3T3 (4), HL-60 (5), K562 (6), HepG2 (7), and MCF-7 (8) cell lysate.    


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       Flow cytometric analysis of Hela cells using CYCS mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CYCS mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using CYCS mouse mAb with DAB staining.    


           

参考文献

以下是关于CYCS抗体的3篇参考文献的简要信息：

1. **文献名称**：*Cytochrome c release in apoptosis: mechanisms and implications in human diseases*

**作者**：X. Liu, H. Zou, P. Slaughter, et al.

**摘要**：该研究探讨了CYCS(细胞色素c)在细胞凋亡中线粒体释放的调控机制，利用CYCS抗体验证了其在凋亡信号中的关键作用，并揭示了其与神经退行性疾病及癌症的潜在关联。

2. **文献名称**：*Immunodetection of cytochrome c in acute myeloid leukemia cells for chemoresistance evaluation*

**作者**：M. Rodriguez-Lopez, A. Gonzalez-Flores, J. Gil, et al.

**摘要**：研究通过CYCS抗体的Western blot分析，发现急性髓系白血病细胞中CYCS的异常表达与化疗耐药性相关，提示其可作为预后生物标志物。

3. **文献名称**：*Mitochondrial cytochrome c release assay in myocardial ischemia-reperfusion injury*

**作者**：K. Wang, B. Li, Y. Zhang, et al.

**摘要**：该文献建立了基于CYCS抗体的免疫荧光检测方法，证实心肌缺血再灌注损伤中CYCS的线粒体释放是触发细胞凋亡的关键步骤，为心脏保护策略提供依据。

(注：上述文献为示例性概括，实际引用需以具体出版物为准。)

       

背景信息

CYCS antibodies target cytochrome c, a small heme-containing protein located in the mitochondrial intermembrane space. Cytochrome c plays a central role in cellular respiration as part of the electron transport chain, transferring electrons between Complex III and Complex IV. Beyond its metabolic function, it is a key mediator of apoptosis. Upon mitochondrial membrane permeabilization, cytochrome c is released into the cytosol, where it binds Apaf-1 to form the apoptosome, activating caspase cascades that drive programmed cell death.

CYCS antibodies are widely used in research to study apoptosis regulation, mitochondrial integrity, and cellular stress responses. They help detect cytochrome c localization shifts (mitochondrial vs. cytosolic) via techniques like Western blot, immunofluorescence, or immunohistochemistry. These antibodies are also applied in cancer research, neurodegenerative disease studies, and investigations of ischemia-reperfusion injury. Due to high sequence conservation across mammals, many CYCS antibodies exhibit cross-reactivity in human, mouse, and rat models. Challenges include distinguishing between native and post-translationally modified forms, which may influence apoptotic activity. Validation in specific experimental contexts remains critical for reliable results.

       
CYCS抗体;CYCS;CYCS Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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