XIAP抗体—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of Hela cells using XIAP mouse mAb (green) and negative control (red).    

  
  

XIAP (X-linked inhibitor of apoptosis) antibodies are tools used to study the XIAP protein, a key regulator of programmed cell death (apoptosis). XIAP, encoded by the *BIRC4* gene, belongs to the inhibitor of apoptosis (IAP) family and functions by binding to caspases, enzymes that drive apoptosis, thereby blocking their activity. This anti-apoptotic role makes XIAP critical in cellular survival, immune response modulation, and cancer progression. Structurally, XIAP contains three BIR (baculovirus IAP repeat) domains that inhibit caspases and a RING domain enabling ubiquitin ligase activity for protein degradation.

XIAP antibodies are widely employed in research to detect XIAP expression levels via techniques like Western blotting, immunohistochemistry, and flow cytometry. Dysregulation of XIAP is linked to diseases: overexpression is associated with cancer chemoresistance, while mutations cause X-linked lymphoproliferative syndrome type 2 (XLP-2), a rare immunodeficiency. Researchers also use XIAP antibodies to explore therapeutic strategies, such as small-molecule inhibitors or gene silencing, to counteract XIAP’s pro-survival effects in malignancies. Additionally, these antibodies help elucidate XIAP’s non-apoptotic roles, including NF-κB signaling and inflammatory pathways. As XIAP remains a promising therapeutic target, its antibodies are vital for both mechanistic studies and translational applications in oncology and immunology.