HTRA2抗体—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Western blot analysis using HTRA2 mouse mAb against HL-60 (1), HepG2 (2), MCF-7 (3), Hela (4), PC-12 (5), C2C12 (6), and Raji (7) cell lysate.    

  
  

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     Flow cytometric analysis of Hela cells using HTRA2 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using HTRA2 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using HTRA2 mouse mAb with DAB staining.    

  
  

**Background of HTRA2 Antibody**

HTRA2 (High-temperature requirement A2), also known as OMI, is a mitochondrial serine protease belonging to the evolutionarily conserved HtrA protein family. Primarily localized in the mitochondrial intermembrane space, HTRA2 plays dual roles in cellular homeostasis: it maintains mitochondrial protein quality under stress by degrading misfolded proteins and participates in apoptosis by cleaving inhibitor of apoptosis proteins (IAPs) upon its release into the cytosol. Dysregulation of HTRA2 is linked to neurodegenerative disorders, particularly Parkinson’s disease, where loss-of-function mutations (e.g., in the *PARK13* gene) impair protease activity, leading to mitochondrial dysfunction and neuronal death.

HTRA2 antibodies are essential tools for studying its expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding research into HTRA2’s role in apoptosis, mitochondrial dynamics, and disease mechanisms. These antibodies also help explore therapeutic strategies, such as targeting HTRA2 in cancer (where its pro-apoptotic activity may suppress tumors) or mitigating its dysfunction in neurodegeneration. By facilitating precise protein analysis, HTRA2 antibodies contribute to understanding cellular stress responses and developing targeted therapies.