ACSS1抗体—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Western blot analysis using ACSS1 mouse mAb against MOLT4 (1), Jurkat (2), and HL-60 (3) cell lysate.    

  
  

The ACSS1 (acyl-CoA synthetase short-chain family member 1) antibody is a research tool used to detect and study the ACSS1 protein, an enzyme critical for cellular metabolism. ACSS1 catalyzes the conversion of acetate into acetyl-CoA, a key substrate in lipid synthesis, energy production, and histone acetylation. This enzyme is primarily localized in mitochondria, where it links acetate metabolism to the tricarboxylic acid (TCA) cycle, particularly under low-glucose conditions. Dysregulation of ACSS1 has been implicated in metabolic disorders, cancer, and neurodegenerative diseases, making it a target for therapeutic and diagnostic research.

Antibodies against ACSS1 enable researchers to investigate its expression, localization, and function in tissues or cell lines. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validated antibodies help identify ACSS1’s role in diseases; for example, reduced ACSS1 levels correlate with mitochondrial dysfunction in neurodegenerative conditions, while its overexpression in certain cancers may drive tumor growth via altered acetyl-CoA availability. Researchers also utilize these antibodies to explore ACSS1’s interaction with metabolic pathways or epigenetic regulators, such as histone acetyltransferases. Specificity and cross-reactivity validation are essential, as ACSS1 shares structural homology with other acyl-CoA synthetases. Overall, ACSS1 antibodies are vital for advancing studies in metabolism, oncology, and neurology.